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Please consult your doctor or medical professional for medical advice
Dupixent is used with other asthma medicines for the maintenance treatment of severe asthma in adults and adolescents (aged 12 and older) whose asthma is not controlled with their current asthma medicines. This medicine contains the active substance dupilumab.
Dupixent is a monoclonal antibody (a type of specialised protein) that blocks the action of two proteins called Interleukin 4 (IL-4) and Interleukin 13 (IL-13). IL-4 and IL-13 can trigger signals that lead to lung inflammation, causing the symptoms of asthma. Dupixent helps prevent severe asthma attacks (exacerbation) and can improve your breathing.
Dupixent is not a rescue medicine and should not be used to treat a sudden asthma attack. Remember to not change or stop other asthma medicines without talking to your healthcare professional.
Dupixent is given by injection under your skin. You and your healthcare professional decide if you should inject this medicine yourself. Always use this medicine exactly as your healthcare professional has told you.
Inject this medicine yourself only after you have been trained by your healthcare professional. A caregiver may also give you an injection after proper training.
You can inject into your thigh or belly (stomach), except for the 5 cm around your navel. If somebody else gives you the injection, they can also use your upper arm. Change the injection site for each injection. Do not inject into skin that is tender, damaged or has bruises or scars. Ensure you have the following: the Dupixent pre-filled syringe or pen, 1 alcohol wipe, 1 cotton ball or gauze, and a puncture-resistant container. Please follow all instructions outlined in the Instructions for Use in the Dupixent pack and ask your healthcare professional if you have any questions.
Watch the video on how to take Dupixent
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Your healthcare professional will decide how much Dupixent you need and for how long. The recommended dose of Dupixent for adults and adolescents (12 years of age and older) is:
An initial dose of 400 mg (two 200 mg injections), followed by 200 mg every other week administered as subcutaneous injection.
For patients with severe asthma and who are on oral corticosteroids or for patients with severe asthma and co-morbid moderate-to-severe atopic dermatitis or adults with co-morbid severe chronic rhinosinusitis with nasal polyposis, the recommended dose is an initial dose of 600 mg (two 300 mg injections), followed by 300 mg every other week administered as subcutaneous injection.
Do not stop using Dupixent without speaking to your healthcare professional first.
If you use more Dupixent than you should, or forget to use Dupixent, please contact your healthcare professional immediately.
If a dose is missed, or if you use more Dupixent than you should, or the dose has been given too early, talk to your doctor, pharmacist, or nurse.
Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the label and carton after expiry as "EXP". The expiry date refers to the last day of that month. Store Dupixent in a refrigerator (2°C to 8°C). Pre-filled syringes or pens may be kept at room temperature for a maximum of 14 days. Do not store above 25°C. Do not freeze. Store in the original carton to protect from light. Do not use this medicine if you notice that the medicine is cloudy, discoloured, or has particles in it.
Your healthcare professional will decide how much Dupixent you need and for how long. Do not stop using Dupixent without speaking to your healthcare professional first.
Because of the chronic (recurring) nature of the disease, the inflammation causing the symptoms of asthma may still be present even if you do not have asthma exacerbation. So you should continue to take Dupixent as prescribed, even if your breathing improves, to continue the clinical benefits of the medicine.
Do not use Dupixent if you are or think you are allergic to dupilumab or any of the other ingredients of this medicine. If you think you may be allergic, or you are not sure, ask your healthcare professional for advice before using this medicine.
Pregnancy and breast-feeding
If you're pregnant, think you may be pregnant, or are planning to have a baby, ask your healthcare professional for advice before using this medicine. The effects of this medicine in pregnant women are not known; therefore, it is preferable to avoid the use of Dupixent in pregnancy unless your healthcare professional advises to use it. If you are planning to breast-feed, you and your healthcare professional should decide if you will breast-feed or use this medicine. You should not do both.
Very rarely, Dupixent can cause serious side effects, including allergic (hypersensitivity) reactions. You must look out for signs of these conditions such as breathing problems, swelling of the face, mouth and tongue, fainting, dizziness, feeling lightheaded (low blood pressure), fever, general ill feeling, swollen lymph nodes, hives, itching, joint pain, skin rash while you are taking this medicine. Stop using this medicine and tell your healthcare professional or get medical help immediately if you notice any signs of an allergic reaction.
Rarely patients taking an asthma medicine may develop inflammation of blood vessels or lungs due to an increase of certain white blood cells (eosinophilia). Tell your doctor immediately if you develop a combination of symptoms such as a flu-like illness, pins and needles or numbness of arms or legs, worsening of pulmonary symptoms, and/or rash.
Parasitic (intestinal parasites) infection
Dupixent may weaken your resistance to infections caused by parasites. If you already have a parasitic infection, it should be treated before you start treatment with this medicine. Check with your healthcare professional if you have diarrhoea, gas, upset stomach, greasy stools, and dehydration which could be a sign of a parasitic infection. If you live in a region where these infections are common or if you are travelling to such a region, check with your healthcare professional.
Talk to your healthcare professional if you have any new or worsening eye problems, including eye pain or changes in vision.
Talk to your healthcare professional if you have recently had or are due to have a vaccination.
(may affect more than 1 in 10 people):
(may affect up to 1 in 10 people):
Dupixent is subject to additional monitoring. This will allow quick identification of new safety information. If you get any side effects, talk to your healthcare professional. This includes any possible side effects not listed in the package leaflet. You can also report side effects directly via the Yellow Card Scheme at
Health information contained herein is provided for general educational purposes only. Your doctor is the single best source of information regarding your health. Please consult your doctor if you have any questions about your health or treatment.